Virus-like particles-flexible platforms for vaccine development

被引：243

作者：

Chackerian, Bryce ^{[1
]}

机构：

[1] Univ New Mexico, Sch Med, Ctr Infect Dis & Immun,Canc Res & Treatment Ctr, Dept Mol Genet & Microbiol,Canc Biol Program, Albuquerque, NM 87131 USA

来源：

EXPERT REVIEW OF VACCINES | 2007年 / 6卷 / 03期

关键词：

antibody induction; cytotoxic T lyinphocyte; self-antigen; virus-fike particle;

D O I：

10.1586/14760584.6.3.381

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Virus-like particles (VLPs) consist of viral structural proteins that, when overexpressed, spontaneously self-assemble into particles that are antigenically indistinguishable from infectious virus or subviral particles. VLPs can be considered as dense, repetitive arrays of one or more protein subunits with properties that are highly advantageous for use as stand-alone vaccines or as vaccine platforms. This review discusses the development of VLP-based platform technologies for vaccines against pathogens, as well as nontraditional targets such as self-antigens involved in chronic diseases.

引用

页码：381 / 390

页数：10

共 103 条

[61] Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease [J].

Morgan, D ;

Diamond, DM ;

Gottschall, PE ;

Ugen, KE ;

Dickey, C ;

Hardy, J ;

Duff, K ;

Jantzen, P ;

DiCarlo, G ;

Wilcock, D ;

Connor, K ;

Hatcher, J ;

Hope, C ;

Gordon, M ;

Arendash, GW .

NATURE, 2000, 408 (6815) :982-985

[62] New tools for antigen delivery to the MHC class I pathway [J].

Morón, G ;

Dadaglio, G ;

Leclerc, C .

TRENDS IN IMMUNOLOGY, 2004, 25 (02) :92-97

[63] CD8α- CD11b+ dendritic cells present exogenous virus-like particles to CD8+ T cells and subsequently express CD8α and CD205 molecules [J].

Morón, G ;

Rueda, P ;

Casal, I ;

Leclerc, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (10) :1233-1245

[64] Human papillomavirus type 16 virus-like particles expressed in attenuated Salmonella typhimurium elicit mucosal and systemic neutralizing antibodies in mice [J].

NardelliHaefliger, D ;

Roden, RBS ;

Benyacoub, J ;

Sahli, R ;

Kraehenbuhl, JP ;

Schiller, JT ;

Lachat, P ;

Potts, A ;

DeGrandi, P .

INFECTION AND IMMUNITY, 1997, 65 (08) :3328-3336

[65] Phase I testing of a malaria vaccine composed of hepatitis B virus core particles expressing Plasmodium falciparum circumsporozoite epitopes [J].

Nardin, EH ;

Oliveira, GA ;

Calvo-Calle, JM ;

Wetzel, K ;

Maier, C ;

Birkett, AJ ;

Sarpotdar, P ;

Corado, ML ;

Thornton, GB ;

Schmidt, A .

INFECTION AND IMMUNITY, 2004, 72 (11) :6519-6527

[66] A universal influenza A vaccine based on the extracellular domain of the M2 protein [J].

Neirynck, S ;

Deroo, T ;

Saelens, X ;

Vanlandschoot, P ;

Jou, WM ;

Fiers, W .

NATURE MEDICINE, 1999, 5 (10) :1157-1163

[67] CLONAL DELETION OF LYMPHOCYTE-B IN A TRANSGENIC MOUSE BEARING ANTI-MHC CLASS-I ANTIBODY GENES [J].

NEMAZEE, DA ;

BURKI, K .

NATURE, 1989, 337 (6207) :562-566

[68] Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide:: a case report [J].

Nicoll, JAR ;

Wilkinson, D ;

Holmes, C ;

Steart, P ;

Markham, H ;

Weller, RO .

NATURE MEDICINE, 2003, 9 (04) :448-452

[69]

Nieland JD, 1999, J CELL BIOCHEM, V73, P145, DOI 10.1002/(SICI)1097-4644(19990501)73:2<145::AID-JCB1>3.0.CO

[70]

2-5

← 2 3 4 5 6 7 8 9 10 11 →