Congenital hypofibrinogenemia in pregnancy: Report of two cases and review of the literature

Fibrinogen abnormalities have been implicated in many adverse pregnancy outcomes, mainly spontaneous abortion, placental abruption, and postpartum hemorrhage. Two new cases of congenital hypofibrinogenemia in pregnancy are reported detailing their obstetric course and management. The relevant obstetric and hematologic literature is reviewed, including previous case reports and studies concerning the mechanisms of pregnancy complications. Suggestions for treatment guidelines and management strategies are detailed. Target Audience: Obstetricians & Gynecologists, Family Physicians Learning Objectives: After completion of this article, the reader should be able to describe how fibrinogen is synthesized and how it functions, to explain the various fibrinogen abnormalities, to outline the various ramifications and manifestations of a patient with a fibrinogen abnormality, and to describe the treatment for fibrinogen abnormalities during pregnancy.