Aerosol and subcutaneous measles vaccine: Measles antibody responses 6 years after re-vaccination

被引：42

作者：

Dilraj, Athmanundh

Sukhoo, Reshma

Cutts, Felicity T.

Bennett, John V.

机构：

[1] MRC, Unit Clin & Biomed TB Res, ZA-4001 Durban, South Africa

[2] London Sch Hyg & Trop Med, Infect Dis Epidemiol Unit, London WC1, England

[3] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

来源：

VACCINE | 2007年 / 25卷 / 21期

关键词：

aerosol measles re-vaccination; antibody responses;

D O I：

10.1016/j.vaccine.2007.03.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There are no large-scale data on the long-term persistence of measles antibody after vaccination by the aerosol route. We therefore followed-up South African schoolchildren 6 years after their re-vaccination with Edmonston-Zagreb (EZ) and Schwarz (SW) measles vaccine given by aerosol and subcutaneous routes. Measles antibody levels and the proportion of children who were seropositive at year 6 remained significantly higher in the Edmonston-Zagreb aerosol group compared to the groups that received Schwarz or Edmonston-Zagreb vaccine subcutaneously. Measles re-vaccination by aerosol evokes a stronger and much Ion er lasting antibody response than injected vaccine and should thus provide more durable protection against measles. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4170 / 4174

页数：5

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