学术探索
学术期刊
新闻热点
数据分析
智能评审

RecQ helicases: Caretakers of the genome

被引：554
作者：
Hickson, ID [1 ]
机构：
[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Canc Res UK Labs, Oxford OX3 9DS, England
来源：
NATURE REVIEWS CANCER | 2003年 / 3卷 / 03期
关键词：
D O I：
10.1038/nrc1012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans give rise to debilitating disorders that are characterized by, amongst other things, a predisposition to the development of cancer. One of these disorders - Bloom's syndrome - is uniquely associated with a predisposition to cancers of all types. So how do RecQ helicases protect against cancer? They seem to maintain genomic stability by functioning at the interface between DNA replication and DNA repair.
引用
收藏
页码：169 / 178
页数：10
相关论文
共 117 条
  • [1] Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM
    Beamish, H
    Kedar, P
    Kaneko, H
    Chen, P
    Fukao, T
    Peng, C
    Beresten, S
    Gueven, N
    Purdie, D
    Lees-Miller, S
    Ellis, N
    Kondo, N
    Lavin, MF
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (34) : 30515 - 30523
  • [2] Bennett RJ, 2000, J BIOL CHEM, V275, P26898
  • [3] Regulation and localization of the Bloom syndrome protein in response to DNA damage
    Bischof, O
    Kim, SH
    Irving, J
    Beresten, S
    Ellis, NA
    Campisi, J
    [J]. JOURNAL OF CELL BIOLOGY, 2001, 153 (02) : 367 - 380
  • [4] Physical and functional interaction between p53 and the Werner's syndrome protein
    Blander, G
    Kipnis, J
    Leal, JFM
    Yu, CE
    Schellenberg, GD
    Oren, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (41) : 29463 - 29469
  • [5] Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity
    Brosh, RM
    Li, JL
    Kenny, MK
    Karow, JK
    Cooper, MP
    Kureekattil, RP
    Hickson, ID
    Bohr, VA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (31) : 23500 - 23508
  • [6] Biochemical characterization of the WRN-FEN-1 functional interaction
    Brosh, RM
    Driscoll, HC
    Dianov, GL
    Sommers, JA
    [J]. BIOCHEMISTRY, 2002, 41 (40) : 12204 - 12216
  • [7] Brosh RM, 2001, EMBO J, V20, P5791
  • [8] Functional and physical interaction between WRN helicase and human replication protein A
    Brosh, RM
    Orren, DK
    Nehlin, JO
    Ravn, PH
    Kenny, MK
    Machwe, A
    Bohr, VA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) : 18341 - 18350
  • [9] p53 modulates the exonuclease activity of Werner syndrome protein
    Brosh, RM
    Harmakar, P
    Sommers, JA
    Yang, Q
    Wang, XW
    Spillare, EA
    Harris, CC
    Bohr, VA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (37) : 35093 - 35102
  • [10] Mammalian DNA mismatch repair
    Buermeyer, AB
    Deschênes, SM
    Baker, SM
    Liskay, RM
    [J]. ANNUAL REVIEW OF GENETICS, 1999, 33 : 533 - 564
12345678910