Diastereoselective manipulations of bicyclo[m.1.0]alkane derivatives.: 5.: α′-alkylations of bicyclo[m.1.0]alkan-2-ones

被引：5

作者：

Mash, EA ^{[1
]}

Baron, JA ^{[1
]}

Gregg, TM ^{[1
]}

Nimkar, SK ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 12期

关键词：

D O I：

10.1016/S0040-4020(98)83003-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha'-Alkylations of bicyclo[m.1.0]alkan-2-ones were shown to proceed with high diastereoselectivity under conditions which favor kinetic control of the product distribution. Product yields for active electrophiles were good to very good. In sequential alpha'-alkylations with different electrophiles, reversal of the order of alkylation switches the configuration of the newly formed quaternary center. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2669 / 2682

页数：14

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