Potential for Targeting the Fibroblast Growth Factor Receptors in Breast Cancer

被引：57

作者：

Hynes, Nancy E. ^{[1
]}

Dey, Julien H. ^{[1
]}

机构：

[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

来源：

CANCER RESEARCH | 2010年 / 70卷 / 13期

关键词：

GENOME-WIDE ASSOCIATION; FGFR1; AMPLIFICATION; KINASE INHIBITOR; THERAPY; RESISTANCE; CARCINOMA; ONCOGENE; SURVIVAL; TUMORS; INT-2;

D O I：

10.1158/0008-5472.CAN-10-0918

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Breast cancer is the most common cancer of women, accounting yearly for approximately 30% of newly diagnosed cases and ranking second as a cause of death. Despite improvements in breast cancer detection and development of new therapeutic approaches, there are still tumors for which no targeted therapies are available. This review summarizes recent findings on the fibroblast growth factor receptors (FGFR) and the data supporting their role in breast cancer. We will describe the approaches being made to develop therapeutics targeting these receptors. Finally, to improve the chances for success with FGFR signal transduction inhibitors, strategies to choose appropriate breast cancer patients for treatment will be discussed. Cancer Res; 70(13); 5199-202. (C) 2010 AACR.

引用

页码：5199 / 5202

页数：4

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