Inhibitors for expression of IgE receptor on human mast cell from Puerariae Flos

被引：27

作者：

Tamura, Satoru ^{[1
]}

Yoshihira, Kunichika ^{[1
]}

Tokumaru, Mariko ^{[1
]}

Xu Zisheng ^{[1
]}

Murakami, Nobutoshi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Osaka 5650871, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 13期

关键词：

Fc epsilon RI; Anti-allergy; Tectorigenin; Isoflavone; Pueraria thomsonii Benth; Puerariae Flos;

D O I：

10.1016/j.bmcl.2010.05.038

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Bioassay-guided separation of the extract of the medicinal plant, Puerariae Flos, disclosed the two isoflavones tectorigenin (1) and genistein (2) as the inhibitors for expression of IgE receptor (Fc epsilon RI), the key molecule triggering the allergic reactions, on human mast cells. As a result of analysis of structure-activity relationship of the naturally occurring and synthesized isoflavones, 7-O-methyl glycitein (11) was disclosed as the more potent inhibitor than tectorigenin (1). These isoflavone ingredients suppressed expression of FceRI more potently than the active flavonoids found previously. In addition, tectorigenin (1) was clarified to particularly reduce generation of gamma-chain subunit to suppress expression of FceRI among the three subunits. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3872 / 3875

页数：4

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