Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand

被引：30

作者：

Chang, S. Y.

Yong, T. F.

Yu, C. Y.

Liang, M. C.

Pletnikova, O.

Troncoso, J.

Burgunder, J. -M

Soong, T. W.

机构：

[1] Natl Univ Singapore, Dept Physiol, Loo Lin Sch Med, Singapore 117597, Singapore

[2] Natl Neurosci Inst, Singapore 308433, Singapore

[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[5] Univ Bern, Dept Neurol, CH-3010 Bern, Switzerland

[6] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA

来源：

NEUROSCIENCE | 2007年 / 145卷 / 03期

关键词：

calcium channel; EF hand; mutually-exclusive exons; developmental switch; aging;

D O I：

10.1016/j.neuroscience.2006.12.054

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ca(v)2.1 Ca2+ channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its alternatively-spliced exons is 37, which forms part of the EF hand. The expression of exon 37a (EFa form), but not exon 37b (EFb form), confers the channel an activity-dependent enhancement of channel opening known as Ca2+-dependent facilitation (CDF). In this study, we analyzed the trend of EF hand splice variant distributions in mouse, rat and human brain tissues. We observed a developmental switch in rodents, as well as an age and gender bias in human brain tissues, suggestive of a possible role of these EF hand splice variants in neurophysiological specialization. A parallel study performed on rodent brains showed that the data drawn from human and rodent tissues may not necessarily correlate in the process of aging. (c) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：1026 / 1036

页数：11

共 63 条

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