Nicotine addiction and nicotinic receptors: lessons from genetically modified mice

被引：346

作者：

Changeux, Jean-Pierre ^{[1
,2
]}

机构：

[1] Coll France, F-75015 Paris, France

[2] Inst Pasteur, CNRS, URA 2182, F-75015 Paris, France

来源：

NATURE REVIEWS NEUROSCIENCE | 2010年 / 11卷 / 06期

关键词：

VENTRAL TEGMENTAL AREA; WHITE-MATTER INTEGRITY; LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; ACETYLCHOLINE-RECEPTORS; PREFRONTAL CORTEX; IN-VIVO; DOPAMINE RELEASE; BEHAVIORAL CHARACTERIZATION; SYNAPTIC-TRANSMISSION;

D O I：

10.1038/nrn2849

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The past decades have seen a revolution in our understanding of brain diseases and in particular of drug addiction. This has been largely due to the identification of neurotransmitter receptors and the development of animal models, which together have enabled the investigation of brain functions from the molecular to the cognitive level. Tobacco smoking, the principal - yet avoidable - cause of lung cancer is associated with nicotine addiction. Recent studies in mice involving deletion and replacement of nicotinic acetylcholine receptor subunits have begun to identify the molecular mechanisms underlying nicotine addiction and might offer new therapeutic strategies to treat this addiction.

引用

页码：389 / 401

页数：13

共 151 条

[1] Repeated high-frequency transcranial magnetic stimulation over the dorsolateral prefrontal cortex reduces cigarette craving and consumption [J].

Amiaz, Revital ;

Levy, Dino ;

Vainiger, Dana ;

Grunhaus, Leon ;

Zangen, Abraham .

ADDICTION, 2009, 104 (04) :653-660

[2] Interplay of β2*nicotinic receptors and dopamine pathways in the control of spontaneous locomotion [J].

Avale, Maria Elena ;

Faure, Philippe ;

Pons, Stephanie ;

Robledo, Patricia ;

Deltheil, Thierry ;

David, Denis J. ;

Gardier, Alain M. ;

Maldonado, Rafael ;

Granon, Sylvie ;

Changeux, Jean-Pierre ;

Maskos, Uwe .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (41) :15991-15996

[3]

BAKER LK, 2005, SOC NEUR ANN M WASH

[4]

Balfour David J K, 2009, Handb Exp Pharmacol, P209, DOI 10.1007/978-3-540-69248-5_8

[5] Sensitization of the mesoaccumbens dopamine response to nicotine [J].

Balfour, DJK ;

Benwell, MEM ;

Birrell, CE ;

Kelly, RJ ;

Al-Aloul, M .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1998, 59 (04) :1021-1030

[6] The neurobiology of tobacco dependence: A preclinical perspective on the role of the dopamine projections to the nucleus [J].

Balfour, DJK .

NICOTINE & TOBACCO RESEARCH, 2004, 6 (06) :899-912

[7] The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence [J].

Balfour, DJK ;

Wright, AE ;

Benwell, MEM ;

Birrell, CE .

BEHAVIOURAL BRAIN RESEARCH, 2000, 113 (1-2) :73-83

[8] Critical role of the prefrontal cortex in the regulation of hippocampus-accumbens information flow [J].

Belujon, Pauline ;

Grace, Anthony A. .

JOURNAL OF NEUROSCIENCE, 2008, 28 (39) :9797-9805

[9] DESENSITIZATION OF THE NICOTINE-INDUCED MESOLIMBIC DOPAMINE RESPONSES DURING CONSTANT INFUSION WITH NICOTINE [J].

BENWELL, MEM ;

BALFOUR, DJK ;

BIRRELL, CE .

BRITISH JOURNAL OF PHARMACOLOGY, 1995, 114 (02) :454-460

[10] Genetic dissociation of two behaviors associated with nicotine addiction: Beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome [J].

Besson, M. ;

David, V. ;

Suarez, S. ;

Cormier, A. ;

Cazala, P. ;

Changeux, J. -P. ;

Granon, S. .

PSYCHOPHARMACOLOGY, 2006, 187 (02) :189-199

← 1 2 3 4 5 6 7 8 9 10 →