PACAP38 and PACAP27 administered intracerebroventricularly have an opposite effect on LH secretion

被引：18

作者：

Kántor, O

Molnár, J

Arimura, A

Köves, K

机构：

[1] Semmelweis Univ, Dept Human Morphol & Dev Biol, Fac Med, H-1094 Budapest, Hungary

[2] Tulane Univ, Hebert Ctr, US Japan Biomed Res Labs, Belle Chasse, LA 70037 USA

[3] Tulane Univ, Sch Med, Dept Anat & Physiol, New Orleans, LA 70112 USA

来源：

PEPTIDES | 2000年 / 21卷 / 06期

基金：

匈牙利科学研究基金会;

关键词：

PACAP38; PACAP27; VIP; ovulation; LH; rat;

D O I：

10.1016/S0196-9781(00)00214-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of PACAP38 on the LH surge and ovulation was compared with that of PACAP27 and VIP in the same model. The peptides were administered intracerebroventricularly before the critical period of the proestrous stage. PACAP38 was able to inhibit ovulation and to prevent the preovulatory LH surge; however, PACAP27 did not inhibit the ovulation and VIP inhibited the ovulation in 2/11 animals. In those animals of the last two groups in which ovulation occurred, the preovulatory LH surge was higher than in control rats. It is speculated that the opposite effect of PACAP38 and PACAP27 on the preovulatory LH surge and ovulation is possibly mediated through different receptors, (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：817 / 820

页数：4

共 23 条

[1] Pituitary adenylate cyclase-activating polypeptide acts within the medial basal hypothalamus to inhibit prolactin and luteinizing hormone secretion [J].