Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism - A possible mechanism for the development of airway fibrosis in asthma

被引:27
作者
Ingram, JL
Rice, A
Geisenhoffer, K
Madtes, DK
Bonner, JC
机构
[1] NIEHS, Pulm Pathobiol Lab, Res Triangle Pk, NC 27709 USA
[2] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
关键词
D O I
10.1378/chest.123.3_suppl.422S
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
引用
收藏
页码:422S / 424S
页数:3
相关论文
共 10 条
[1]   Interleukin-13 induces proliferation of human airway epithelial cells in vitro via a mechanism mediated by transforming growth factor-α [J].
Booth, BW ;
Adler, KB ;
Bonner, JC ;
Tournier, F ;
Martin, LD .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2001, 25 (06) :739-743
[2]   MYOFIBROBLASTS AND SUBEPITHELIAL FIBROSIS IN BRONCHIAL-ASTHMA [J].
BREWSTER, CEP ;
HOWARTH, PH ;
DJUKANOVIC, R ;
WILSON, J ;
HOLGATE, ST ;
ROCHE, WR .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1990, 3 (05) :507-511
[3]  
Coin PG, 1996, J IMMUNOL, V156, P4797
[4]   Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung [J].
Hancock, A ;
Armstrong, L ;
Gama, R ;
Millar, A .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1998, 18 (01) :60-65
[5]   Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production [J].
Kuperman, D ;
Schofield, B ;
Wills-Karp, M ;
Grusby, MJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (06) :939-948
[6]   Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types [J].
Lee, JH ;
Kaminski, N ;
Dolganov, G ;
Grunig, G ;
Koth, L ;
Solomon, C ;
Erle, DJ ;
Sheppard, D .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2001, 25 (04) :474-485
[7]   INTERLEUKIN-1-BETA (IL-1-BETA) AND THE IL-1-BETA-ALPHA(2)-MACROGLOBULIN COMPLEX UP-REGULATE THE PLATELET-DERIVED GROWTH-FACTOR ALPHA-RECEPTOR ON RAT PULMONARY FIBROBLASTS [J].
LINDROOS, PM ;
COIN, PG ;
OSORNIOVARGAS, AR ;
BONNER, JC .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1995, 13 (04) :455-465
[8]   INTERLEUKIN-1 MITOGENIC ACTIVITY FOR FIBROBLASTS AND SMOOTH-MUSCLE CELLS IS DUE TO PDGF-AA [J].
RAINES, EW ;
DOWER, SK ;
ROSS, R .
SCIENCE, 1989, 243 (4889) :393-396
[9]   Interleukin-13: Central mediator of allergic asthma [J].
Wills-Karp, M ;
Luyimbazi, J ;
Xu, XY ;
Schofield, B ;
Neben, TY ;
Karp, CL ;
Donaldson, DD .
SCIENCE, 1998, 282 (5397) :2258-2261
[10]   Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production [J].
Zhou, Z ;
Homer, RJ ;
Wang, ZD ;
Chen, QS ;
Geba, GP ;
Wang, JM ;
Zhang, Y ;
Elias, JA .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (06) :779-788