Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders

被引：20

作者：

Hashimoto, R

Suzuki, T

Iwata, N

Yamanouchi, Y

Kitajima, T

Kosuga, A

Tatsumi, M

Ozaki, N

Kamijima, K

Kunugi, H

机构：

[1] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, Tokyo 1878502, Japan

[2] Fujita Hlth Univ, Sch Med, Dept Psychiat, Aichi, Japan

[3] Showa Univ, Karasuyama Hosp, Tokyo, Japan

[4] Showa Univ, Sch Med, Dept Psychiat, Tokyo 142, Japan

[5] Yokohama Shinryo Clin, Kanagawa, Japan

[6] Nagoya Univ, Grad Sch Med, Dept Psychiat, Aichi, Japan

来源：

JOURNAL OF NEURAL TRANSMISSION | 2005年 / 112卷 / 02期

关键词：

FZD3; schizophrenia; mood disorder; association study; single nucleotide polymorphism (SNP);

D O I：

10.1007/s00702-004-0264-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two research groups have recently reported a significant association between schizophrenia and genetic variants of Frizzled-3 (FZD3) gene. We examined a possible association in a Japanese sample of schizophrenia, bipolar disorder, unipolar depression and controls with four single nucleotide polymorphisms (SNPs), tested in previous reports. We failed to find significant association in the four SNPs or haplotype analysis. The FZD3 gene might not play a role in conferring susceptibility to major psychosis in our sample.

引用

页码：303 / 307

页数：5

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