Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis

被引：53

作者：

Shimizu, T ^{[1
]}

Tomita, Y ^{[1
]}

Son, K ^{[1
]}

Nishinarita, S ^{[1
]}

Sawada, S ^{[1
]}

Horie, T ^{[1
]}

机构：

[1] Nihon Univ, Sch Med, Dept Internal Med 1, Tokyo, Japan

来源：

CLINICAL RHEUMATOLOGY | 2000年 / 19卷 / 05期

关键词：

dermatomyositis; polymyositis; soluble TNF receptor 1; soluble TNF receptor 2; TNF-receptor; 1; 2;

D O I：

10.1007/s100670070027

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of the study was, to examine the relationship between serum levels of soluble tumour necrosis factor receptors (sTNF-R) and the gene expression of two types of receptor for TNF (TNF-R) a 55 kDa receptor (TNF-R1) and a 75 kDa receptor (TNF-R2). in peripheral blood mononuclear cells (PBMC) from patients with polymyositis and dermatomyositis (PM/DM). Soluble tumour necrosis factor receptor (sTNF-R1) and soluble tumour necrosis factor receptor 2 (sTNF-R2) levels in sera from patients were measured by enzyme-linked immunosorbent assay. Expression of TNF-R1 and TNF-R2 mRNAs in PBMC was analysed by Northern blotting. Serum sTNF-R1 and sTNF-R2 levels were elevated significantly in 25 patients with active-stage PM/DM: compared to those in 18 patients with inactive-stage PM/DM and 32 normal controls. Serum concentrations of sTNF-R1 and sTNF-R2 were correlated with PM/DM disease activity. TNF-R1 ene expression was enhanced in freshly isolated PBMC from patients with active-stage PM/DM. In contrast, TNF-R2 mRNA was expressed constitutively in patients with active-stage PM/DM and in normal controls. The expression of TNF-R1 and TNF-R2 mRNAs in PBMC and elevation of their soluble forms in the sera of patients with active-stage PM/DM suggest increased proteolytic cleavage of cell surface TNF-R from PBMC in patients with active-stage PM/DM, and that sTNF-R may regulate TNF-x-mediated muscle fibre damage in PM/DM.

引用

页码：352 / 359

页数：8

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