Electrophoretic enantiomer separations at high pH using the new, single-isomer octakis(2,3-dimethyl-6-O-sulfo)-γ-cyclodextrin as chiral resolving agent

The latest, single-isomer, sulfated gamma-cyclodextrin, the sodium salt of octakis(2,3-dimethyl-6-O-sulfo)-gamma-cyclodextrin that is stable in basic media was used to separate the enantiomers of neutral, weak acid and weak base analytes by capillary electrophoresis in high pH aqueous background electrolytes. The effective mobilities and separation selectivities were found to follow trends similar to those observed earlier in acidic aqueous background electrolytes. Octakis(2,3-dimethyl-6-O-sulfo)-gamma-cyclodextrin proved to interact with all three analyte types less strongly than other single-isomer sulfated cyclodextrins do under comparable conditions. (C) 2002 Elsevier Science B.V. All rights reserved.