Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage

被引：35

作者：

Capasso, R

Pinto, L

Vuotto, ML

Di Carlo, G

机构：

[1] Univ Naples Federico II, Dept Expt Pharmacol, I-80131 Naples, Italy

[2] Dept Pharmaceut Sci, I-84084 Salerno, Italy

[3] Univ Naples 2, Inst Gen Pathol & Oncol, Naples, Italy

来源：

FITOTERAPIA | 2000年 / 71卷

关键词：

eugenol; antiulcer activity; platelet activating factor (PAF); ethanol;

D O I：

10.1016/S0367-326X(00)00188-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study examines the anti-ulcerogenic activity of eugenol, a natural compound obtained from many natural sources. Gastric ulcers, induced by administration of two ulcerogenic agents, i.e, platelet activating factor (PAF) and ethanol, were dose-dependently and significantly reduced by eugenol (10-100 mg/kg, p.o.) pre-treatment. Eugenol was able to reduce not only the number of ulcers but also the gravity of lesions. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：S131 / S137

页数：7

共 17 条

[1]

BENNETT A, 1988, PHYTOTER RES, V3, P124

[2] GASTRIC-MUCOSAL DAMAGE INDUCED IN RATS BY INTRAVENOUS ADMINISTRATION OF PLATELET-ACTIVATING FACTOR [J].