Nitric oxide mediates mecamylamine- and naloxone-precipitated nicotine withdrawal

被引：21

作者：

Adams, ML ^{[1
]}

Cicero, TJ ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 345卷 / 02期

关键词：

nitric oxide (NO); nicotine dependence;

D O I：

10.1016/S0014-2999(98)00089-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A nitric oxide synthase inhibitor blocked nicotine abstinence signs and increased weight loss in male, nicotine-dependent rats during withdrawal precipitated by the nicotinic receptor antagonist mecamylamine or the opioid receptor antagonist naloxone. These results indicate that nitric oxide systems mediate important aspects of the expression of nicotine physical dependence and suggest the potential use of nitric oxide synthase inhibitors as aids in tobacco smoking cessation. (C) 1998 Elsevier Science B.V.

引用

页码：R1 / R2

页数：2

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