Associative plasticity in surround inhibition circuits in human motor cortex

被引:5
作者
Belvisi, Daniele [1 ]
Kassavetis, Panagiotis [2 ]
Bologna, Matteo [1 ]
Edwards, Mark J. [2 ]
Berardelli, Alfredo [1 ,2 ,3 ]
Rothwell, John C. [2 ]
机构
[1] Neuromed Inst IRCCS, I-86077 Pozzilli, IS, Italy
[2] UCL Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London, England
[3] Univ Roma La Sapienza, Dept Neurol & Psychiat, I-00185 Rome, Italy
关键词
cortical plasticity; motor control; movement; neurophysiology; transcranial magnetic stimulation; TRANSCRANIAL MAGNETIC STIMULATION; FOCAL HAND DYSTONIA; CORTICAL SILENT PERIOD; WRITERS CRAMP; INTRACORTICAL INHIBITION; PARKINSONS-DISEASE; ORGANIZATION; NEURONS; MUSCLE; EXCITABILITY;
D O I
10.1111/ejn.12738
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Surround inhibition is a physiological mechanism that is hypothesised to improve contrast between signals in the central nervous system. In the human motor system, motor surround inhibition (mSI) can be assessed using transcranial magnetic stimulation (TMS). We evaluated whether it is possible to modulate mSI, using a paradigm able to induce plastic effects in primary motor cortex (M1). Fifteen healthy volunteers participated in the experiments. To assess mSI, we delivered single pulses at rest and at the onset of a right thumb abduction. TMS pulses over abductor digiti minimi (ADM; surround muscle) hotspot were delivered when EMG activity in right abductor pollicis brevis (APB; active muscle) >100V was detected. Paired associative stimulation (PAS) was delivered using peripheral median nerve electric stimulation and TMS over APB M1 area at an interstimulus interval of 21.5ms for the real PAS (PAS21.5) and 100ms for the sham PAS (PAS100). To verify the effect of PAS21.5 on mSI we collected 20 MEPs from ADM at rest and during APB movements before (T0) and 5 (T1), 15 (T2) and 30 (T3) minutes after PAS21.5. mSI from APB to ADM was present at baseline. PAS21.5 increased the amount of mSI compared with baseline whereas there was no effect after PAS100. Our results suggest that mSI is an adaptable phenomenon depending on prior experience.
引用
收藏
页码:3704 / 3710
页数:7
相关论文
共 44 条
[1]
Angelucci A, 2002, PROG BRAIN RES, V136, P373
[2]
Surround inhibition depends on the force exerted and is abnormal in focal hand dystonia [J].
Beck, S. ;
Schubert, M. ;
Richardson, S. Pirio ;
Hallett, M. .
JOURNAL OF APPLIED PHYSIOLOGY, 2009, 107 (05) :1513-1518
[3]
Surround inhibition in the motor system [J].
Beck, Sandra ;
Hallett, Mark .
EXPERIMENTAL BRAIN RESEARCH, 2011, 210 (02) :165-172
[4]
Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia [J].
Belvisi, Daniele ;
Suppa, Antonio ;
Marsili, Luca ;
Di Stasio, Flavio ;
Parvez, Ahmad Khandker ;
Agostino, Rocco ;
Fabbrini, Giovanni ;
Berardelli, Alfredo .
EXPERIMENTAL NEUROLOGY, 2013, 240 :64-74
[5]
LATERAL INHIBITION BETWEEN ORIENTATION DETECTORS IN HUMAN VISUAL SYSTEM [J].
BLAKEMOR.C ;
CARPENTE.RH ;
GEORGESO.MA .
NATURE, 1970, 228 (5266) :37-&
[6]
RECIPROCAL INHIBITION IN WRITERS CRAMP [J].
CHEN, RS ;
TSAI, CH ;
LU, CS .
MOVEMENT DISORDERS, 1995, 10 (05) :556-561
[7]
Shortened cortical silent period in facial muscles of patients with cranial dystonia [J].
Currà, A ;
Romaniello, A ;
Berardelli, A ;
Cruccu, G ;
Manfredi, M .
NEUROLOGY, 2000, 54 (01) :130-135
[8]
Modulation of motor cortex neuronal networks by rTMS: comparison of local and remote effects of six different protocols of stimulation [J].
Di Lazzaro, V. ;
Dileone, M. ;
Pilato, F. ;
Capone, F. ;
Musumeci, G. ;
Ranieri, F. ;
Ricci, V. ;
Bria, P. ;
Di Iorio, R. ;
de Waure, C. ;
Pasqualetti, P. ;
Profice, P. .
JOURNAL OF NEUROPHYSIOLOGY, 2011, 105 (05) :2150-2156
[9]
Short-interval intracortical inhibition blocks long-term potentiation induced by paired associative stimulation [J].
Elahi, Behzad ;
Gunraj, Carolyn ;
Chen, Robert .
JOURNAL OF NEUROPHYSIOLOGY, 2012, 107 (07) :1935-1941
[10]
Impairment of cortical inhibition in writer's cramp as revealed by changes in electromyographic silent period after transcranial magnetic stimulation [J].
Filipovic, SR ;
Ljubisavljevic, M ;
Svetel, M ;
Milanovic, S ;
Kacar, A ;
Kostic, VS .
NEUROSCIENCE LETTERS, 1997, 222 (03) :167-170