Review: Fetal-maternal communication via extracellular vesicles - Implications for complications of pregnancies

被引：73

作者：

Adam, Stefanie ^{[1
]}

Elfeky, Omar ^{[1
]}

Kinhal, Vyjayanthi ^{[1
]}

Dutta, Suchismita ^{[1
]}

Lai, Andrew ^{[1
]}

Jayabalan, Nanthini ^{[1
]}

Nuzhat, Zarin ^{[1
]}

Palma, Carlos ^{[1
]}

Rice, Gregory E. ^{[1
,2
]}

Salomon, Carlos ^{[1
,2
]}

机构：

[1] Univ Queensland, Clin Res Ctr, Ctr Clin Diagnost, Exosome Biol Lab,Royal Brisbane & Womens Hosp, Brisbane, Qld 4029, Australia

[2] Ochsner Clin Fdn, Dept Obstet & Gynecol, Maternal Fetal Med, New Orleans, LA USA

来源：

PLACENTA | 2017年 / 54卷

关键词：

Placenta; Exosomes; Extracellular vesicles; Pregnancy; PLACENTA-DERIVED EXOSOMES; UMBILICAL-CORD BLOOD; 1ST TRIMESTER; INTERCELLULAR COMMUNICATION; TROPHOBLAST CELLS; OXIDATIVE STRESS; EARLY-ONSET; STEM-CELLS; PREECLAMPSIA; CIRCULATION;

D O I：

10.1016/j.placenta.2016.12.001

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

The maternal physiology experiences numerous changes during pregnancy which are essential in controlling and maintaining maternal metabolic adaptations and fetal development. The human placenta is an organ that serves as the primary interface between the maternal and fetal circulation, thereby supplying the fetus with nutrients, blood and oxygen through the umbilical cord. During gestation, the placenta continuously releases several molecules into maternal circulation, including hormones, proteins, RNA and DNA. Interestingly, the presence of extracellular vesicles (EVs) of placental origin has been identified in maternal circulation across gestation. EVs can be categorised according to their size and/or origin into microvesicles (similar to 150-1000 nm) and exosomes (similar to 40-120 nm). Microvesicles are released by budding from the plasmatic membrane, whereas exosome release is by fusion of multivesicular bodies with the plasmatic membrane. Exosomes released from placental cells have been found to be regulated by oxygen tension and glucose concentration. Furthermore, maternal exosomes have the ability to stimulate cytokine release from endothelial cells. In this review, we will discuss the role of EVs during fetal-maternal communication during gestation with a special emphasis on exosomes. (C) 2016 Published by Elsevier Ltd.

引用

页码：83 / 88

页数：6

共 61 条

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