Synapses: Glia help synapses form and function

被引:9
作者
Smith, SJ [1 ]
机构
[1] Stanford Univ, Sch Med, Beckman Ctr, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA
关键词
D O I
10.1016/S0960-9822(98)70099-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A sophisticated new cell culture system has shown that glial cells can promote synaptogenesis and enhance the efficacy of synaptic transmission. These effects are not secondary to increased neuronal survival but probably involve changes in neuronal activity levels and a secreted glial factor.
引用
收藏
页码:R158 / +
页数:4
相关论文
共 12 条
[1]   AMINO-ACID NEUROTRANSMITTER TRANSPORTERS - STRUCTURE, FUNCTION, AND MOLECULAR DIVERSITY [J].
CLARK, JA ;
AMARA, SG .
BIOESSAYS, 1993, 15 (05) :323-332
[2]   Long-term potentiation and functional synapse induction in developing hippocampus [J].
Durand, GM ;
Kovalchuk, Y ;
Konnerth, A .
NATURE, 1996, 381 (6577) :71-75
[3]  
Goslin K., 1991, CULTURING NERVE CELL, P251
[4]   SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS - CRITICAL ROLE FOR GLIAL-CELLS [J].
KEYSER, DO ;
PELLMAR, TC .
GLIA, 1994, 10 (04) :237-243
[5]   Silent synapses speak up [J].
Malenka, RC ;
Nicoll, RA .
NEURON, 1997, 19 (03) :473-476
[6]   Neural development: How cadherins zipper up neural circuits [J].
Martinek, S ;
Gaul, U .
CURRENT BIOLOGY, 1997, 7 (11) :R712-R715
[7]   GLIAL CONTRIBUTIONS TO EXCITATORY NEUROTRANSMISSION IN CULTURED HIPPOCAMPAL CELLS [J].
MENNERICK, S ;
ZORUMSKI, CF .
NATURE, 1994, 368 (6466) :59-62
[8]   Synaptic efficacy enhanced by glial cells in vitro [J].
Pfrieger, FW ;
Barres, BA .
SCIENCE, 1997, 277 (5332) :1684-1687
[9]   Optical detection of a quantal presynaptic membrane turnover [J].
Ryan, TA ;
Reuter, H ;
Smith, SJ .
NATURE, 1997, 388 (6641) :478-482
[10]   Potentiation of evoked vesicle turnover at individually resolved synaptic boutons [J].
Ryan, TA ;
Ziv, NE ;
Smith, SJ .
NEURON, 1996, 17 (01) :125-134