Synthesis of a new class of spin-labeled purine ribonucleosides and development of a novel nucleophilic reaction to form 2,6,8-trifunctionalized purine derivatives

被引：6

作者：

Aso, M ^{[1
]}

Norihisa, K ^{[1
]}

Tanaka, M ^{[1
]}

Koga, N ^{[1
]}

Suemune, H ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 8128582, Japan

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 2000年 / 08期

关键词：

Amino acids - Aromatization - Derivatives - Oxidation - Paramagnetic resonance - Silver compounds - Spectroscopy - Substitution reactions - Synthesis (chemical);

D O I：

10.1039/b004445h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel purine ribonucleosides with a tert-butylhydroxyamino function at the C8-position of the purine nucleus were synthesized, and were oxidized to aminoxyl radicals by treatment with Ag2O; after O-acylation of the tert-butylhydroxyamino group, nucleophilic substitution at the C2-position of the purine nucleus easily proceeded with elimination of the N-acyloxy group to provide a novel method for preparing C2-functionalized purine ribonucleosides.

引用

页码：1637 / 1638

页数：2

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