Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria

被引：17

作者：

Jensen, ATR

Zornig, HD

Buhmann, C

Salanti, A

Koram, KA

Riley, EM

Theander, TG

Hviid, L

Staalsoe, T

机构：

[1] Rigshosp, Dept Infect Dis M7641, Ctr Med Parasitol, DK-2200 Copenhagen N, Denmark

[2] Univ Copenhagen, Inst Med Microbiol & Immunol, Copenhagen, Denmark

[3] Univ Ghana, Epidemiol Unit, Noguchi Mem Inst Med Res, Legon, Ghana

[4] London Sch Hyg & Trop Med, London WC1, England

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 07期

关键词：

D O I：

10.1128/IAI.71.7.4193-4196.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.

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页码：4193 / 4196

页数：4

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