Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase

被引：21

作者：

Dankwardt, SM ^{[1
]}

Billedeau, RJ ^{[1
]}

Lawley, LK ^{[1
]}

Abbot, SC ^{[1
]}

Martin, RL ^{[1
]}

Chan, CS ^{[1
]}

Van Wart, HE ^{[1
]}

Walker, KAM ^{[1
]}

机构：

[1] Roche Biosci, Inflammatory Dis Unit, Palo Alto, CA 94304 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(00)00525-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP). (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2513 / 2516

页数：4