Lactic acid bacteria as a cell factory:: rerouting of carbon metabolism in Lactococcus lactis by metabolic engineering

被引：77

作者：

Kleerebezem, M

Hols, P

Hugenholtz, J

机构：

[1] NIZO Food Res, Wageningen Ctr Food Sci, NL-6710 AB Ede, Netherlands

[2] NIZO Food Res, Microbial Ingredients Sect, NL-6710 AB Ede, Netherlands

来源：

ENZYME AND MICROBIAL TECHNOLOGY | 2000年 / 26卷 / 9-10期

关键词：

lactic acid bacteria; Lactococcus lactis; metabolic engineering; pyruvate metabolism; NICE system;

D O I：

10.1016/S0141-0229(00)00180-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lactic acid bacteria display a relatively simple metabolism wherein the sugar is converted mainly to lactic acid. The extensive knowledge of metabolic pathways and the increasing information of the genes involved allows For the rerouting of natural metabolic pathways by genetic and physiological engineering. We discuss several examples of metabolic engineering of Lactococcus lactis for the production of important compounds, including diacetyl, alanine and exopolysaccharides, (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：840 / 848

页数：9

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