TriTrypDB: a functional genomic resource for the Trypanosomatidae

被引：649

作者：

Aslett, Martin ^{[2
]}

Aurrecoechea, Cristina ^{[3
]}

Berriman, Matthew ^{[2
]}

Brestelli, John ^{[1
]}

Brunk, Brian P. ^{[1
]}

Carrington, Mark ^{[4
]}

Depledge, Daniel P. ^{[2
]}

Fischer, Steve ^{[1
]}

Gajria, Bindu ^{[1
]}

Gao, Xin ^{[1
]}

Gardner, Malcolm J. ^{[5
,6
]}

Gingle, Alan ^{[7
]}

Grant, Greg ^{[1
]}

Harb, Omar S. ^{[1
]}

Heiges, Mark ^{[3
]}

Hertz-Fowler, Christiane ^{[2
]}

Houston, Robin ^{[2
]}

Innamorato, Frank ^{[1
]}

Iodice, John ^{[1
]}

Kissinger, Jessica C. ^{[3
,8
]}

Kraemer, Eileen ^{[9
]}

Li, Wei ^{[1
]}

Logan, Flora J. ^{[2
]}

Miller, John A. ^{[9
]}

Mitra, Siddhartha ^{[6
]}

Myler, Peter J. ^{[5
,6
,10
]}

Nayak, Vishal ^{[1
]}

Pennington, Cary ^{[3
]}

Phan, Isabelle ^{[6
]}

Pinney, Deborah F. ^{[1
]}

Ramasamy, Gowthaman ^{[6
]}

Rogers, Matthew B. ^{[2
]}

Roos, David S. ^{[11
]}

Ross, Chris ^{[3
]}

Sivam, Dhileep ^{[6
]}

Smith, Deborah F. ^{[12
]}

Srinivasamoorthy, Ganesh ^{[3
]}

Stoeckert, Christian J., Jr. ^{[1
]}

Subramanian, Sandhya ^{[6
]}

Thibodeau, Ryan ^{[3
]}

Tivey, Adrian ^{[2
]}

Treatman, Charles ^{[1
]}

Velarde, Giles ^{[2
]}

Wang, Haiming ^{[3
]}

机构：

[1] Univ Penn, Penn Ctr Bioinformat, Philadelphia, PA 19104 USA

[2] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England

[3] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 USA

[4] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[5] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[6] Seattle Biomed Res Inst, Seattle, WA 98109 USA

[7] Univ Georgia, Ctr Appl Genet Technol, Athens, GA 30602 USA

[8] Univ Georgia, Dept Genet, Athens, GA 30602 USA

[9] Univ Georgia, Dept Comp Sci, Athens, GA 30602 USA

[10] Univ Washington, Dept Med Educ & Biomed Informat, Seattle, WA 98195 USA

[11] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

[12] Univ York, Dept Biol, Ctr Immunol & Infect, York YO10 5YW, N Yorkshire, England

来源：

NUCLEIC ACIDS RESEARCH | 2010年 / 38卷

基金：

美国国家卫生研究院; 比尔及梅琳达.盖茨基金会; 英国惠康基金;

关键词：

CRUZI;

D O I：

10.1093/nar/gkp851

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TriTrypDB (http://tritrypdb.org) is an integrated database providing access to genome-scale datasets for kinetoplastid parasites, and supporting a variety of complex queries driven by research and development needs. TriTrypDB is a collaborative project, utilizing the GUS/WDK computational infrastructure developed by the Eukaryotic Pathogen Bioinformatics Resource Center (EuPathDB.org) to integrate genome annotation and analyses from GeneDB and elsewhere with a wide variety of functional genomics datasets made available by members of the global research community, often pre-publication. Currently, TriTrypDB integrates datasets from Leishmania braziliensis, L. infantum, L. major, L. tarentolae, Trypanosoma brucei and T. cruzi. Users may examine individual genes or chromosomal spans in their genomic context, including syntenic alignments with other kinetoplastid organisms. Data within TriTrypDB can be interrogated utilizing a sophisticated search strategy system that enables a user to construct complex queries combining multiple data types. All search strategies are stored, allowing future access and integrated searches. 'User Comments' may be added to any gene page, enhancing available annotation; such comments become immediately searchable via the text search, and are forwarded to curators for incorporation into the reference annotation when appropriate.

引用

页码：D457 / D462

页数：6

共 19 条

[1]

[Anonymous], 2006, WEEKLY EPIDEMIOLOGIC, V82, P71

[2] The Trypanosoma cruzi proteome [J].

Atwood, JA ;

Weatherly, DB ;

Minning, TA ;

Bundy, B ;

Cavola, C ;

Opperdoes, FR ;

Orlando, R ;

Tarleton, RL .

SCIENCE, 2005, 309 (5733) :473-476

[3] ApiDB: integrated resources for the apicomplexan bioinformatics resource center [J].

Aurrecoechea, Cristina ;

Heiges, Mark ;

Wang, Haiming ;

Wang, Zhiming ;

Fischer, Steve ;

Rhodes, Philippa ;

Miller, John ;

Kraemer, Eileen ;

Stoeckert, Christian J., Jr. ;

Roos, David S. ;

Kissinger, Jessica C. .

NUCLEIC ACIDS RESEARCH, 2007, 35 :D427-D430

[4] The genome of the African trypanosome Trypanosoma brucei [J].

Berriman, M ;

Ghedin, E ;

Hertz-Fowler, C ;

Blandin, G ;

Renauld, H ;

Bartholomeu, DC ;

Lennard, NJ ;

Caler, E ;

Hamlin, NE ;

Haas, B ;

Böhme, W ;

Hannick, L ;

Aslett, MA ;

Shallom, J ;

Marcello, L ;

Hou, LH ;

Wickstead, B ;

Alsmark, UCM ;

Arrowsmith, C ;

Atkin, RJ ;

Barron, AJ ;

Bringaud, F ;

Brooks, K ;

Carrington, M ;

Cherevach, I ;

Chillingworth, TJ ;

Churcher, C ;

Clark, LN ;

Corton, CH ;

Cronin, A ;

Davies, RM ;

Doggett, J ;

Djikeng, A ;

Feldblyum, T ;

Field, MC ;

Fraser, A ;

Goodhead, I ;

Hance, Z ;

Harper, D ;

Harris, BR ;

Hauser, H ;

Hostetter, J ;

Ivens, A ;

Jagels, K ;

Johnson, D ;

Johnson, J ;

Jones, K ;

Kerhornou, AX ;

Koo, H ;

Larke, N .

SCIENCE, 2005, 309 (5733) :416-422

[5] Artemis and ACT: viewing, annotating and comparing sequences stored in a relational database [J].

Carver, Tim ;

Berriman, Matthew ;

Tivey, Adrian ;

Patel, Chinmay ;

Bohme, Ulrike ;

Barrell, Barclay G. ;

Parkhill, Julian ;

Rajandream, Marie-Adele .

BIOINFORMATICS, 2008, 24 (23) :2672-2676

[6] OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups [J].

Chen, Feng ;

Mackey, Aaron J. ;

Stoeckert, Christian J., Jr. ;

Roos, David S. .

NUCLEIC ACIDS RESEARCH, 2006, 34 :D363-D368

[7] History of sleeping sickness (African trypanosomiasis) [J].

Cox, FEG .

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2004, 18 (02) :231-+

[8] The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease [J].

El-Sayed, NM ;

Myler, PJ ;

Bartholomeu, DC ;

Nilsson, D ;

Aggarwal, G ;

Tran, AN ;

Ghedin, E ;

Worthey, EA ;

Delcher, AL ;

Blandin, G ;

Westenberger, SJ ;

Caler, E ;

Cerqueira, GC ;

Branche, C ;

Haas, B ;

Anupama, A ;

Arner, E ;

Åslund, L ;

Attipoe, P ;

Bontempi, E ;

Bringaud, F ;

Burton, P ;

Cadag, E ;

Campbell, DA ;

Carrington, M ;

Crabtree, J ;

Darban, H ;

da Silveira, JF ;

de Jong, P ;

Edwards, K ;

Englund, PT ;

Fazelina, G ;

Feldblyum, T ;

Ferella, M ;

Frasch, AC ;

Gull, K ;

Horn, D ;

Hou, LH ;

Huang, YT ;

Kindlund, E ;

Ktingbeil, M ;

Kluge, S ;

Koo, H ;

Lacerda, D ;

Levin, MJ ;

Lorenzi, H ;

Louie, T ;

Machado, CR ;

McCulloch, R ;

McKenna, A .

SCIENCE, 2005, 309 (5733) :409-415

[9] GeneDB: a resource for prokaryotic and eukaryotic organisms [J].

Hertz-Fowler, C ;

Peacock, CS ;

Wood, V ;

Aslett, M ;

Kerhornou, A ;

Mooney, P ;

Tivey, A ;

Berriman, M ;

Hall, N ;

Rutherford, K ;

Parkhill, J ;

Ivens, AC ;

Rajandream, MA ;

Barrell, B .

NUCLEIC ACIDS RESEARCH, 2004, 32 :D339-D343

[10] The Neglected Tropical Diseases of Latin America and the Caribbean: A Review of Disease Burden and Distribution and a Roadmap for Control and Elimination [J].

Hotez, Peter J. ;

Bottazzi, Maria Elena ;

Franco-Paredes, Carlos ;

Ault, Steven K. ;

Periago, Mirta Roses .

PLOS NEGLECTED TROPICAL DISEASES, 2008, 2 (09)

← 1 2 →