White matter changes in schizophrenia - Evidence for myelin-related dysfunction

被引:653
作者
Davis, KL
Stewart, DG
Friedman, JI
Buchsbaum, M
Harvey, PD
Hof, PR
Buxbaum, J
Haroutunian, V
机构
[1] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10021 USA
[2] Mt Sinai Sch Med, Kastor Neurobiol Aging Labs, Fishberg Res Ctr Neurobiol, New York, NY 10021 USA
[3] Mt Sinai Sch Med, Kastor Neurobiol Aging Labs, Dept Geriatr Adult Dev, New York, NY 10021 USA
[4] Bronx Vet Adm Med Ctr, Mental Illness Res Educ & Clin Ctr, Bronx, NY USA
[5] Pilgrim Psychiat Ctr, Brentwood, NY USA
关键词
D O I
10.1001/archpsyc.60.5.443
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Numerous lines of inquiry implicate connectivity as a central abnormality in schizophrenia. Myelination and factors that affect myelination, such. as the function of oligodendroglia, are critical processes that could profoundly affect neuronal connectivity, especially given the diffuse distribution of oligodendrocytes and the widespread distribution of brain regions that have been implicated in schizophrenia. Multiple lines of evidence now converge to implicate oligodendroglia and myelin in schizophrenia. Imaging and neurocytochemical evidence, similarities with demyelinating diseases, age-related changes in white matter, myelin-related gene abnormalities, and morphologic abnormalities in the oligodendroglia demonstrated in schizophrenic brains are all examined in light of the hypothesis that oligodendroglial dysfunction and even death, with subsequent abnormalities in myelin maintenance and repair, contribute to the schizophrenic syndrome.
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收藏
页码:443 / 456
页数:14
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