Photoluminescent Carbon Dots as Biocompatible Nanoprobes for Targeting Cancer Cells in Vitro

被引：294

作者：

Li, Qin ^{[1
]}

Ohulchanskyy, Tymish Y. ^{[2
]}

Liu, Ruili ^{[3
]}

Koynov, Kaloian ^{[4
]}

Wu, Dongqing ^{[4
]}

Best, Andreas ^{[4
]}

Kumar, Rajiv ^{[2
]}

Bonoiu, Adela ^{[2
]}

Prasad, Paras N. ^{[2
]}

机构：

[1] Curtin Univ Technol, Dept Chem Engn, Perth, WA 6845, Australia

[2] SUNY Buffalo, Inst Laser Photon & Biophoton, Buffalo, NY 14260 USA

[3] Shanghai Univ, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China

[4] Max Planck Inst Polymer Res, D-55128 Mainz, Germany

来源：

JOURNAL OF PHYSICAL CHEMISTRY C | 2010年 / 114卷 / 28期

基金：

澳大利亚研究理事会; 中国国家自然科学基金;

关键词：

RECEPTOR-MEDIATED ENDOCYTOSIS; DIAMOND NANOPARTICLES; QUANTUM DOTS; NANOTUBES; BRIGHT; CYTOTOXICITY; LUMINESCENCE;

D O I：

10.1021/jp911539r

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Carbon nanoparticles become photoluminescent upon surface passivation with oligomeric polymer chains. In this work, the dependence of the carbon dots photoluminescent properties on the passivation polymer selection has been demonstrated by conjugating polyethylene glycol (PEG) chains, polyethylenimide-co-polyethylene glycol-co-polyethylenimide copolymer, and 4-armed PEG molecules, respectively. The cytotoxicity and cellular internalization of the resulting three types of photoluminescent nanoformulations of carbon dots, named CD2, CD3, and CD4, were evaluated. These nanoforinulations exhibited no apparent cytotoxicity on their own and were shown to successfully target cancer cells by conjugation with transferrin. The implication to the use of carbon dots as biocompatible optical nanoprobes for in vitro cancer diagnostics is discussed.

引用

页码：12062 / 12068

页数：7

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