Intranuclear neuronal inclusions: A common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

被引:321
作者
Ross, CA [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Psychiat, Div Neurobiol,Lab Mol Neurobiol, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Neurosci, Div Neurobiol,Lab Mol Neurobiol, Baltimore, MD 21205 USA
关键词
D O I
10.1016/S0896-6273(00)80405-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
[No abstract available]
引用
收藏
页码:1147 / 1150
页数:4
相关论文
共 15 条
  • [1] Rethinking genotype and phenotype correlations in polyglutamine expansion disorders
    Andrew, SE
    Goldberg, YP
    Hayden, MR
    [J]. HUMAN MOLECULAR GENETICS, 1997, 6 (12) : 2005 - 2010
  • [2] BECHER MW, 1997, IN PRESS NEUROBIOL D, V4
  • [3] Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rad guanine nucleotide exchange factor domain
    Colomer, V
    Engelender, S
    Sharp, AH
    Duan, K
    Cooper, JK
    Lanahan, A
    Lyford, G
    Worley, P
    Ross, CA
    [J]. HUMAN MOLECULAR GENETICS, 1997, 6 (09) : 1519 - 1525
  • [4] Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
    Davies, SW
    Turmaine, M
    Cozens, BA
    DiFiglia, M
    Sharp, AH
    Ross, CA
    Scherzinger, E
    Wanker, EE
    Mangiarini, L
    Bates, GP
    [J]. CELL, 1997, 90 (03) : 537 - 548
  • [5] Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    DiFiglia, M
    Sapp, E
    Chase, KO
    Davies, SW
    Bates, GP
    Vonsattel, JP
    Aronin, N
    [J]. SCIENCE, 1997, 277 (5334) : 1990 - 1993
  • [6] Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
    Goldberg, YP
    Nicholson, DW
    Rasper, DM
    Kalchman, MA
    Koide, HB
    Graham, RK
    Bromm, M
    KazemiEsfarjani, P
    Thornberry, NA
    Vaillancourt, JP
    Hayden, MR
    [J]. NATURE GENETICS, 1996, 13 (04) : 442 - 449
  • [7] The genetic defect causing Huntington's disease: Repeated in other contexts?
    Gusella, JF
    Persichetti, F
    MacDonald, ME
    [J]. MOLECULAR MEDICINE, 1997, 3 (04) : 238 - 246
  • [8] The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1
    Matilla, A
    Koshy, BT
    Cummings, C
    Isobe, T
    Orr, HT
    Zoghbi, HY
    [J]. NATURE, 1997, 389 (6654) : 974 - 978
  • [9] Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells
    Onodera, O
    Burke, JR
    Miller, SE
    Hester, S
    Tsuji, S
    Roses, AD
    Strittmatter, WJ
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 238 (02) : 599 - 605
  • [10] Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse
    Ordway, JM
    TallaksenGreene, S
    Gutekunst, CA
    Bernstein, EM
    Cearley, JA
    Wiener, HW
    Dure, LS
    Lindsey, R
    Hersch, SM
    Jope, RS
    Albin, RL
    Detloff, PJ
    [J]. CELL, 1997, 91 (06) : 753 - 763