T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions

被引：128

作者：

Benagiano, M

Azzurri, A

Ciervo, A

Amedei, A

Tamburini, C

Ferrari, M

Telford, JL

Baldari, CT

Romagnani, S

Cassone, A

D'Elios, MM

Del Prete, G

机构：

[1] Univ Florence, Dept Internal Med, I-50134 Florence, Italy

[2] Ist Super Sanita, Dept Bacteriol & Med Mycol, I-00161 Rome, Italy

[3] Univ Hosp Pisa, Unit Vasc Surg, I-56124 Pisa, Italy

[4] Chiron Vaccines, I-53100 Siena, Italy

[5] Univ Siena, Dept Evolutionary Biol, I-53100 Siena, Italy

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 11期

关键词：

D O I：

10.1073/pnas.1135726100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Atherosclerotic lesions are infiltrated by macrophages and T lymphocytes, potentially reactive to pathogens. We studied in vivo activated T lymphocytes that infiltrate atherosclerotic plaques of Helicobacter pylori-infected patients with or without anti-Chlamydia pneumoniae antibodies. In all atherosclerotic lesions, T helper type 1 (Th1) cells were predominant. C pneumoniae-specific T cells were detected only in the plaques of anti-C pneumoniae seropositive patients, whereas H. pylori-specific T cells were found in the gastric mucosa but not in the plaques of the same patients. Plaque-derived Th1 cells expressed cytotoxicity, proapoptotic activity, and help for monocyte tissue factor, production. Although multifactorial, atherosclerosis can be regarded as a Th1-driven immunopathological condition.

引用

页码：6658 / 6663

页数：6

共 54 条

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