Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria

被引：20

作者：

O'Meara, Wendy Prudhomme

Hall, B. Fenton

McKenzie, F. Ellis

机构：

[1] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA

[2] NIAID, NIH, Rockville, MD USA

来源：

MALARIA JOURNAL | 2007年 / 6卷 / 1期

关键词：

D O I：

10.1186/1475-2875-6-36

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

New sources of funding have revitalized efforts to control malaria. An effective vaccine would be a tremendous asset in the fight against this devastating disease and increasing financial and scientific resources are being invested to develop one. A few candidates have been tested in Phase I and II clinical trials, and several others are poised to begin trials soon. Some studies have been promising, and others disappointing. It is difficult to compare the results of these clinical trials; even independent trials of the same vaccine give highly discrepant results. One major obstacle in evaluating malaria vaccines is the difficulty of diagnosing clinical malaria. This analysis evaluates the impact of diagnostic error, particularly that introduced by microscopy, on the outcome of efficacy trials of malaria vaccines and make recommendations for improving future trials.

引用

页数：10

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