l(2)41Aa, a heterochromatic gene of Drosophila melanogaster is required for mitotic and meiotic chromosome condensation

被引：10

作者：

Cenci, G

Belloni, G

Dimitri, P

机构：

[1] Univ Roma La Sapienza, Dipartimento Genet & Biol Mol Charles Darwin, I-00185 Rome, Italy

[2] Univ Lecce, Dipartimento Sci & Tencol Biol & Ambientali, I-73100 Lecce, Italy

来源：

GENETICS RESEARCH | 2003年 / 81卷 / 01期

关键词：

D O I：

10.1017/S0016672302006018

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic and cytological approaches have yielded significant insight into the mapping and organization of genes located in the heterochromatin of Drosophila melanogaster. To date, only a few of these genes have been molecularly characterized in detail, and their function unveiled. As a further step towards the identification of heterochromatic gene functions, we have carried out a cytological analysis of mitotic and meiotic cell divisions in mutants carrying different allelic combinations of l(2)41Aa, a gene located in the proximal heterochromatin of chromosome 2. Our results showed that larval brains of l(2)41Aa mutants display a high frequency of cells with irregularly condensed chromosomes. In addition, defective chromosome condensation was detected in male meiosis, consequently affecting chromosome segregation and giving rise to irregular spermatids. Taken together, these findings indicate that l(2)41Aa is a novel cell cycle gene required for proper chromosome condensation in both somatic and germ line cells.

引用

页码：15 / 24

页数：10

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