An aminoglycoside antibiotic, neamine, and its aromatic ring-substituted derivatives as potential inhibitors for HIV-I RRE-Rev

被引：20

作者：

Hamasaki, K ^{[1
]}

Woo, MC ^{[1
]}

Ueno, A ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Bioengn, Grad Sch Biosci & Biotechnol, Yokohama, Kanagawa 2268501, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 43期

关键词：

amino sugars; antibiotics; fluorescence; nucleic acids;

D O I：

10.1016/S0040-4039(00)01449-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The binding affinities of ten aminoglycosides with RRE IIB RNA have been determined. Neamine was found as the simplest consensus unit of aminoglycoside antibiotics that bind RRE IIB RNA tightly. Various aromatic ring-substituted neamines have been prepared and their binding with RRE IIB RNA was examined. Among them, pyrene-substituted neamine has shown a submicromolar level of binding with the RNA. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：8327 / 8332

页数：6

共 14 条

[1] alpha helix-RNA major groove recognition in an HIV-1 Rev peptide RRE RNA complex [J].

Battiste, JL ;

Mao, HY ;

Rao, NS ;

Tan, RY ;

Muhandiram, DR ;

Kay, LE ;

Frankel, AD ;

Williamson, JR .

SCIENCE, 1996, 273 (5281) :1547-1551

[2] ANALYSIS OF ARGININE-RICH PEPTIDES FROM THE HIV TAT PROTEIN REVEALS UNUSUAL FEATURES OF RNA PROTEIN RECOGNITION [J].

CALNAN, BJ ;

BIANCALANA, S ;

HUDSON, D ;

FRANKEL, AD .

GENES & DEVELOPMENT, 1991, 5 (02) :201-210

[3] REGULATORY PATHWAYS GOVERNING HIV-1 REPLICATION [J].

CULLEN, BR ;

GREENE, WC .

CELL, 1989, 58 (03) :423-426

[4]

FOURMY D, 1996, SCIENCE, V274, P1307

[5] Minimal RNA constructs that specifically bind aminoglycoside antibiotics with high affinities [J].

Hamasaki, K ;

Killian, J ;

Cho, JY ;

Rando, RR .

BIOCHEMISTRY, 1998, 37 (02) :656-663

[6] A new class of HIV-1 Tat antagonist acting through Tat-TAR inhibition [J].

Hamy, F ;

Brondani, V ;

Flörsheimer, A ;

Stark, W ;

Blommers, MJJ ;

Klimkait, T .

BIOCHEMISTRY, 1998, 37 (15) :5086-5095

[7]

KJEMS J, 1992, EMBO J, V11, P119

[8] HIV-1 STRUCTURAL GENE-EXPRESSION REQUIRES THE BINDING OF MULTIPLE REV MONOMERS TO THE VIRAL RRE - IMPLICATIONS FOR HIV-1 LATENCY [J].

MALIM, MH ;

CULLEN, BR .

CELL, 1991, 65 (02) :241-248

[9] A high-throughput screening utilizing intramolecular fluorescence resonance energy transfer for the discovery of the molecules that bind HIV-1 TAR RNA specifically [J].

Matsumoto, C ;

Hamasaki, K ;

Mihara, H ;

Ueno, A .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (16) :1857-1861

[10] HIV TAR - AN RNA ENHANCER [J].

SHARP, PA ;

MARCINIAK, RA .

CELL, 1989, 59 (02) :229-230

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