We extend strong/weak coupling duality to string theories without spacetime supersymmetry, and focus on the case of the unique ten-dimensional, nonsupersymmetric, tachyon-free SO(16)X SO(16) heterotic string. We construct a tachyon-free heterotic string model that interpolates smoothly between this string and the ten-dimensional supersymmetric SO(32) heterotic string, and we construct a dual for this interpolating model. We find that the perturbative massless states of our dual theories precisely match within a certain range of the interpolation. Further evidence for this proposed duality comes from a calculation of the one-loop cosmological constant in both theories, as well as the presence of a soliton in the dual theory. This is therefore the first known duality relation between nonsupersymmetric tachyon-free string theories. Using this duality, we then investigate the perturbative and nonperturbative stability of the SO(16)X SO(16) string, and present a conjecture concerning its ultimate fate. (C) 1997 Elsevier Science B.V.