Bilateral globus pallidus stimulation for Huntington's disease

被引：128

作者：

Moro, E

Lang, AE

Strafella, AP

Poon, YYW

Arango, PM

Dagher, A

Hutchison, WD

Lozano, AM

机构：

[1] Toronto Western Hosp, Movement Disorders Ctr, Toronto, ON M5T 2S8, Canada

[2] McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada

[3] Toronto Western Hosp, Div Neurosurg, Toronto, ON M5T 2S8, Canada

[4] Univ Toronto, Dept Physiol, Toronto, ON, Canada

来源：

ANNALS OF NEUROLOGY | 2004年 / 56卷 / 02期

关键词：

D O I：

10.1002/ana.20183

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) was performed in a patient with Huntington's disease (HD) with severe chorea. Stimulation at 40 and 130Hz improved chorea. Stimulation at 130Hz slightly worsened bradykinesia overall, whereas 40Hz had little effect. A [O-15] H2O positron emission tomography showed increased regional cerebral blood flow in motor decision making and execution areas more evident at 40Hz. Adjustment of stimulation parameters in GPi DBS may have the potential to optimize the motor response in HD, improving chorea without aggravating bradykinesia.

引用

页码：290 / 294

页数：5

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