Iridoids and Lignans from Valeriana jatamansi

被引：137

作者：

Lin, Sheng ^{[1
]}

Chen, Tao ^{[3
,4
]}

Liu, Xiao-Hua ^{[1
]}

Shen, Yun-Heng ^{[1
]}

Li, Hui-Liang ^{[1
]}

Shan, Lei ^{[1
]}

Liu, Run-Hui ^{[1
]}

Xu, Xi-Ke ^{[1
]}

Zhang, Wei-Dong ^{[1
,2
]}

Wang, Hui ^{[3
,4
]}

机构：

[1] Second Mil Med Univ, Coll Pharm, Dept Phytochem, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 04期

关键词：

COLORIMETRIC ASSAY; ROOTS; SESQUITERPENOIDS; WALLICHII; (+)-EUDESMIN; CONSTITUENTS; OFFICINALIS;

D O I：

10.1021/np900795c

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Thirteen new iridoids including seven iridolactones, jatamanins A-M (1-13), and a new lignan, (+)-9'-isovaleroxylariciresinol (14), together with seven known iridoids and 13 lignans were obtained from whole plants of Valeriana jatamansi. Structures of the new compounds were determined by spectroscopic and crystallographic methods, and the absolute configuration of compound 1 was assigned by application of the modified Mosher method. Jatamanins H (8) and 1 (9) are iridolactones with an unusual C-8-C-11 oxygen bridge, forming a cage-like structure. (+)-9'-Isovaleroxylariciresinol (14) showed significant in vitro cytotoxicity against PC-3M and HCT-8 cell lines, with 1050 values of 8.1 and 5.3 mu M, respectively.

引用

页码：632 / 638

页数：7

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