Bioisosterism: A useful strategy for molecular modification and drug design

被引：565

作者：

Lima, LMA ^{[1
]}

Barreiro, EJ ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Fac Farm, LASSBio, BR-21944190 Rio De Janeiro, Brazil

来源：

CURRENT MEDICINAL CHEMISTRY | 2005年 / 12卷 / 01期

关键词：

D O I：

10.2174/0929867053363540

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review aim to demonstrate the role of bioisosterism in rational drug design as well as in the molecular modification and optimization process aiming to improve pharmacodynamic and pharmacokinetic properties of lead compounds.

引用

页码：23 / 49

页数：27

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