Cystatin C - an accurate marker of glomerular filtration rate after renal transplantation?

被引：39

作者：

Herget-Rosenthal, S ^{[1
]}

Trabold, S ^{[1
]}

Huesing, J ^{[1
]}

Heemann, U ^{[1
]}

Philipp, T ^{[1
]}

Kribben, A ^{[1
]}

机构：

[1] Univ Hosp, Div Nephrol, D-45122 Essen, Germany

来源：

TRANSPLANT INTERNATIONAL | 2000年 / 13卷 / 04期

关键词：

cystatin C; diagnostic test; glomerular filtration rate; kidney transplantation; ROC curve; sensitivity;

D O I：

10.1111/j.1432-2277.2000.tb01083.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The performance of serum cystatin C as a screening marker of reduced creatinine clearance in renal transplantation was evaluated and compared to serum creatinine. In addition we studied whether cystatin C accurately reflects creatinine clearance over the entire range of transplant function. Serum cystatin C, serum creatinine, and creatinine clearance were measured in 110 adult renal transplant recipients. Cystatin C detected reduced creatinine clearance with the high sensitivity of 95 %. Serum cystatin C and serum creatinine did not differ regarding 90 and 95 % sensitivity, derived from the receiver-operating characteristics plot. We demonstrated a strong correlation and linear association between 1/cystatin C and creatinine clearance over the entire range of transplant function, equivalent to that of 1/creatinine. In summary, serum cystatin C accurately reflects creatinine clearance over the entire range of transplant function and is as efficacious as serum creatinine to detect reduced creatinine clearance in renal transplant recipients.

引用

页码：285 / 289

页数：5

共 25 条

[1] STRUCTURE AND EXPRESSION OF THE HUMAN CYSTATIN-C GENE [J].