Neurobiology: At the root of brain cancer

被引:39
作者
Clarke, MF
机构
[1] Univ Michigan, Sch Med, CSCG, Dept Internal Med, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, CSCG, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA
关键词
D O I
10.1038/432281a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A small subpopulation of cells, ‘brain-cancer stem cells’, has been identified in humans. They have the exclusive ability to drive tumour formation, and could prove an effective target for therapies.
引用
收藏
页码:281 / 282
页数:2
相关论文
共 13 条
[1]   Prospective identification of tumorigenic breast cancer cells [J].
Al-Hajj, M ;
Wicha, MS ;
Benito-Hernandez, A ;
Morrison, SJ ;
Clarke, MF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988
[2]   Circulating tumor cells, disease progression, and survival in metastatic breast cancer [J].
Cristofanilli, M ;
Budd, GT ;
Ellis, MJ ;
Stopeck, A ;
Matera, J ;
Miller, MC ;
Reuben, JM ;
Doyle, GV ;
Allard, WJ ;
Terstappen, LWMM ;
Hayes, DF .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (08) :781-791
[3]  
DISTEFANO A, 1979, CANCER, V44, P196, DOI 10.1002/1097-0142(197907)44:1<196::AID-CNCR2820440132>3.0.CO
[4]  
2-H
[5]  
Fialkow P J, 1976, Birth Defects Orig Artic Ser, V12, P123
[6]   A CELL INITIATING HUMAN ACUTE MYELOID-LEUKEMIA AFTER TRANSPLANTATION INTO SCID MICE [J].
LAPIDOT, T ;
SIRARD, C ;
VORMOOR, J ;
MURDOCH, B ;
HOANG, T ;
CACERESCORTES, J ;
MINDEN, M ;
PATERSON, B ;
CALIGIURI, MA ;
DICK, JE .
NATURE, 1994, 367 (6464) :645-648
[7]   Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells [J].
Lessard, J ;
Sauvageau, G .
NATURE, 2003, 423 (6937) :255-260
[8]   Characterization of clonogenic multiple myeloma cells [J].
Matsui, W ;
Huff, CA ;
Wang, QJ ;
Malehorn, MT ;
Barber, J ;
Tanhehco, Y ;
Smith, BD ;
Civin, CI ;
Jones, RJ .
BLOOD, 2004, 103 (06) :2332-2336
[9]   A genetic determinant that specifically regulates the frequency of hematopoietic stem cells [J].
Morrison, SJ ;
Qian, D ;
Jerabek, L ;
Thiel, BA ;
Park, IK ;
Ford, PS ;
Kiel, MJ ;
Schork, NJ ;
Weissman, IL ;
Clarke, MF .
JOURNAL OF IMMUNOLOGY, 2002, 168 (02) :635-642
[10]   Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells [J].
Park, IK ;
Qian, DL ;
Kiel, M ;
Becker, MW ;
Pihalja, M ;
Weissman, IL ;
Morrison, SJ ;
Clarke, MF .
NATURE, 2003, 423 (6937) :302-305