Analysis of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol in biological samples by gas chromatography tandem mass spectrometry (GC/MS-MS)

被引：42

作者：

Chiarotti, M

Costamagna, L

机构：

[1] Univ Cattolica Sacro Cuore, Inst Forens Med, I-00168 Rome, Italy

[2] Univ Roma La Sapienza, Inst Forens Med, Rome, Italy

来源：

FORENSIC SCIENCE INTERNATIONAL | 2000年 / 114卷 / 01期

关键词：

11-nor-carboxy-Delta(9)-tetrahydrocannabinol; cannabis; GC/MS-MS analysis; biological samples; drug testing;

D O I：

10.1016/S0379-0738(00)00248-6

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Gas chromatography tandem mass spectrometry (GC/MS-MS) analysis of 11-nor-carboxy-Delta(9)-tetrahydrocannabinol (Delta(9)-THC-COOH), the major or metabolite of Delta(9)-tetrahydrocannabinol, in biological samples is reported. The proposed method, using deuterated Delta(9)-THC-COOH as an internal standard, is able to detect the major metabolite of cannabis derivatives at very low levels (picograms/millilitre) with high specificity. These characteristics render the proposed analytical procedure suitable for confirmatory analysis in drug testing for cannabis use. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 6

页数：6

共 5 条

[1] A RESEARCH NOTE - THE OUTCOME OF GC/MS/MS CONFIRMATION OF HAIR ASSAYS ON 93 CANNABINOID (+) CASES [J].