Convenient Electrophilic Fluorination of Functionalized Aryl and Heteroaryl Magnesium Reagents

被引：98

作者：

Yamada, Shigeyuki ^{[1
]}

Gavryushin, Andrei ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 12期

基金：

欧洲研究理事会;

关键词：

arenes; electrophilic substitution; fluorination; Grignard reaction; nitrogen heterocycles; NUCLEOPHILIC-SUBSTITUTION; BORONIC ACIDS; TRIFLUOROMETHYLATION; ARYLMAGNESIUM; RADIOLIGAND; NUCLEOSIDES;

D O I：

10.1002/anie.200905052

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemical Equation Presented" Cive me an "F": Electrophilic fluorination of various aromatic and heteroaromatic Grignard reagents is smoothly performed with (PhSO2)2NF as fluorinating agent in a 4:1 mixture of CH2Cl2/ perfluorodecalin (see scheme). This solvent system allows minimization of most side reactions. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA."

引用

页码：2215 / 2218

页数：4

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