COX-2 inhibition, apoptosis, and chemoprevention by nonsteroidal anti-inflammatory drugs

被引：49

作者：

Moore, BC ^{[1
]}

Simmons, DL ^{[1
]}

机构：

[1] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2000年 / 7卷 / 11期

关键词：

D O I：

10.2174/0929867003374273

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-steroidal anti-inflammatory drugs (NSAIDs) have as their common mechanism the inhibition of cyclooxygenase (COX) enzymes, of which two isoforms (COX-1 and COX-2) exist. The effect of NSAIDs on chemoprevention and tumor regression has been shown in animal models, epidemiologic studies, and in treatment of patients. The exact biochemical and cellular mechanisms underlying each of these phenomena is only partially understood. Processes that have been recently implicated as being important include the inhibition of tumor cell growth, prevention of angiogenesis, and induction of apoptosis in neoplastic cells.

引用

页码：1131 / 1144

页数：14

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