Interactions between neural and hormonal mediators of renal vascular tone in anaesthetized rabbits

被引:19
作者
Guild, SJ [1 ]
Barrett, CJ
Evans, RG
Malpas, SC
机构
[1] Univ Auckland, Circulatory Control Lab, Dept Physiol, Auckland 1, New Zealand
[2] Univ Auckland, Circulatory Control Lab, Dept Elect & Elect Engn, Auckland 1, New Zealand
[3] Monash Univ, Dept Physiol, Melbourne, Vic 3168, Australia
关键词
D O I
10.1113/eph8802462
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We investigated how sympathetic nerve activity and vasoactive hormones interact in controlling renal haemodynamics in pentobarbitone-anaesthetized rabbits. Renal blood flow was progressively reduced by electrical stimulation (0.5-3 Hz) of the renal nerves, during renal arterial infusion of saline, vasoconstrictors (angiotensin II and [Phe(2), Ile(3),Orn(8)]-vasopressin), or vasodilators (acetylcholine, adrenomedullin and the nitric oxide donor methylamine hexamethylene NONOate (MAHMA NONOate). A frequency-rich stimulus was also applied to test whether the vasoactive agents affect the dynamic control of renal blood flow by sympathetic nerve activity. The vasodilators tended to increase renal blood flow, but only the effect of MAHMA NONOate was statistically significant. [Phe(2), Ile(3),Orn(8)] -vasopressin reduced medullary perfusion (by 61 +/- 12 %) but not renal blood flow or cortical perfusion. Angiotensin 11 reduced renal blood flow (33 +/- 3 %) and cortical perfusion (14 +/- 5 %) but not medullary perfusion. Steady state responses of renal blood flow and cortical perfusion during renal nerve stimulation were attenuated during infusion of acetylcholine and [Phe(2), Ile(3),Orn(8)] -vasopressin, while angiotensin II attenuated responses of medullary perfusion, and MAHMA NONOate and adrenomedullin had no significant effects. The dynamic response to sympathetic nerve activity (renal blood flow responded as a low pass filter with a pure time delay of similar to664 ms) was not altered by the vasoactive agents. We conclude that some vasoactive agents can modulate steady-state renal haemodynamic responses to sympathetic nerve activity in a regionally specific manner, independent of their effects on baseline renovascular tone. However, they have little impact on the dynamic response of renal blood flow to sympathetic nerve activity.
引用
收藏
页码:229 / 241
页数:13
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