Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line

被引：62

作者：

Moritani, NH

Kubota, S

Nishida, T

Kawaki, H

Kondo, S

Sugahara, T

Takigawa, M

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Dept Biochem & Mol Dent, Okayama 7008525, Japan

[2] Okayama Univ, Grad Sch Med & Dent, Dept Oral & Maxillofacial Reconstruct Surg, Okayama 7008525, Japan

来源：

CANCER LETTERS | 2003年 / 192卷 / 02期

基金：

日本学术振兴会;

关键词：

connective tissue growth factor; oral squamous cell carcinoma; negative regulator; prothymosin alpha;

D O I：

10.1016/S0304-3835(02)00718-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Connective tissue growth factor (CTGF) is known to be a multifunctional growth factor that is overexpressed. in several types of malignancies. In this study, effects of CTGF gene overexpression on the phenotypes of oral squamous cell carcinoma cells were investigated by using a cell line with undetectable endogenous CTGF expression. Surprisingly, our results indicated that CTGF-overexpressed clones were characterized by attenuated cell growth and less potent tumorigenicity, with coincidental downregulation of prothymosin a gene. Although CTGF is known to promote cell proliferation in mesenchymal cells, our present results suggest that CTGF acts as a negative regulator of the cell growth in oral squamous cell carcinoma possibly through its interaction with growth modifiers inside the cell. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：205 / 214

页数：10

共 37 条

[1] CONNECTIVE-TISSUE GROWTH-FACTOR - A CYSTEINE-RICH MITOGEN SECRETED BY HUMAN VASCULAR ENDOTHELIAL-CELLS IS RELATED TO THE SRC-INDUCED IMMEDIATE EARLY GENE-PRODUCT CEF-10 [J].