Aura in some patients with familial hemiplegic migraine can be stopped by intranasal ketamine

被引：147

作者：

Kaube, H

Herzog, J

Käufer, T

Dichgans, M

Diener, HC

机构：

[1] UCL Natl Hosp Neurol & Neurosurg, Inst Neurol, London WC1N 3BG, England

[2] Univ Munich, Klinikum Grosshadern, Dept Neurol, D-8000 Munich, Germany

[3] Univ Essen Gesamthsch, Dept Neurol, D-4300 Essen 1, Germany

来源：

NEUROLOGY | 2000年 / 55卷 / 01期

关键词：

D O I：

10.1212/WNL.55.1.139

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Migraine aura is probably caused by cortical-spreading depression. No treatment for acute and severe migraine aura has been described previously. The effect of ketamine (25 mg intranasally) was studied in 11 patients with severe, disabling auras resulting from familial hemiplegic migraine. In five patients ketamine reproducibly reduced the severity and duration of the neurologic deficits, whereas in the remaining six patients no beneficial effect was seen. Ketamine offers, for the first time, a possible treatment option for severe and prolonged aura.

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页码：139 / 141

页数：3

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