Japanese Alzheimer's Disease Neuroimaging Initiative: Present status and future

Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) was launched in 2008. aiming at conducting a longitudinal workup of a standardized neuroimaging. biomarker and clinicopsychological surveys The research protocol was designed to maximize compatibility with that of US-ADNI. including structural magnetic resonance imaging analysis for the evaluation of brain atrophy. It fluorodeoxyglucose and amyloid positron emission tomograph,,, cerebrospinal fluid sampling, APOE genotyping. together with a set of clinical and psychometric tests that were prepared to achieve the highest compatibility to those used in the United States Japanese ADNI has recruited 357 participants (142 amnestic mild cognitive impairment. 134 normal aged and 72 mild Alzheimer's disease (AD). as of April 15, 2010). World-wide ADNI activities will establish the rigorous quantitative descriptions of the mutual cow se of AD in as very early stages The data, as well as the methodologies and in will facilitate the clinical trials of disease-modifying therapies for AD using surrogate biomarkers (C) 2010 The Alzheimer's Association All rights reserved