Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: a point-counterpoint discussion

被引：57

作者：

Brass, EP

Hiatt, WR

Green, S

机构：

[1] Harbor UCLA Med Ctr, Dept Med, Ctr Clin Pharmacol, Torrance, CA 90509 USA

[2] Colorado Prevent Ctr, Denver, CO 80203 USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Med, Div Geriatr,Sect Vasc Med, Denver, CO 80202 USA

[4] Univ Colorado, Hlth Sci Ctr, Dept Med, Sect Vasc Med,Div Cardiol, Denver, CO 80202 USA

[5] Univ New England, Sch Biol Biomed & Mol Sci, Armidale, NSW, Australia

来源：

VASCULAR MEDICINE | 2004年 / 9卷 / 04期

关键词：

blood flow; intermittent claudication; muscle metabolism; peripheral vascular disease;

D O I：

10.1191/1358863x04vm572ra

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Patients with claudication have a marked impairment in exercise performance. Several factors contribute to this limitation, including reductions in large vessel blood flow and oxygen delivery as well as metabolic abnormalities in skeletal muscle. The relative contribution of these factors and their role in the pathophysiology of the exercise limitation is discussed using a point-counterpoint approach. Future directions for research conclude the discussion.

引用

收藏

页码：293 / 301

页数：9

相关论文

共 83 条

[1] Reversible inhibition of mitochondrial complex IV activity in PBMC following acute smoking [J].

Alonso, JR ;

Cardellach, F ;

Casademont, J ;

Miró, O .

EUROPEAN RESPIRATORY JOURNAL, 2004, 23 (02) :214-218

[2] OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING [J].

AMES, BN ;

SHIGENAGA, MK ;

HAGEN, TM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7915-7922

[3] MECHANISM OF CALF CLAUDICATION - STUDIES OF SIMULTANEOUS CLEARANCE OF TC-99M) FROM CALF AND THIGH [J].

ANGELIDES, N ;

NICOLAIDES, A ;

NEEDHAM, T ;

DUDLEY, H .

BRITISH JOURNAL OF SURGERY, 1978, 65 (03) :204-209

[4] Physiological and symptomatic responses to cycling and walking in intermittent claudication [J].

Askew, CD ;

Green, S ;

Hou, XY ;

Walker, PJ .

CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, 2002, 22 (05) :348-355

[5] ONE MINUTE OXYGEN-UPTAKE IN PERIPHERAL ISCHEMIC VASCULAR-DISEASE [J].

AUCHINCLOSS, JH ;

MEADE, JW ;

GILBERT, R ;

CHAMBERLAIN, BE .

ANNALS OF SURGERY, 1980, 191 (02) :203-206

[6] Walking performance, oxygen uptake kinetics and resting muscle pyruvate dehydrogenase complex activity in peripheral arterial disease [J].

Barker, GA ;

Green, S ;

Green, AA ;

Walker, PJ .

CLINICAL SCIENCE, 2004, 106 (03) :241-249

[7] COMPARISON BETWEEN REACTIVE AND EXERCISE HYPEREMIA IN NORMAL SUBJECTS AND PATIENTS WITH PERIPHERAL ARTERIAL-DISEASE [J].

BARTOLI, V ;

DORIGO, B .

ANGIOLOGY, 1979, 30 (01) :40-47

[8] Oxygen uptake kinetics during exercise are slowed in patients with peripheral arterial disease [J].

Bauer, TA ;

Regensteiner, JG ;

Brass, EP ;

Hiatt, WR .

JOURNAL OF APPLIED PHYSIOLOGY, 1999, 87 (02) :809-816

[9] Impaired muscle oxygen use at onset of exercise in peripheral arterial disease [J].

Bauer, TA ;

Brass, EP ;

Hiatt, WR .

JOURNAL OF VASCULAR SURGERY, 2004, 40 (03) :488-493

[10] Pulmonary Vo2 dynamics during treadmill and arm exercise in peripheral arterial disease [J].

Bauer, TA ;

Brass, EP ;

Nehler, M ;

Barstow, TJ ;

Hiatt, WR .

JOURNAL OF APPLIED PHYSIOLOGY, 2004, 97 (02) :627-634

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