The kinetics of T regulatory cells in shock: beyond sepsis

被引：3

作者：

Christaki, Eirini ^{[1
]}

Patrozou, Eleni ^{[1
]}

机构：

[1] Brown Univ, Warren Alpert Med Sch, Div Infect Dis, Providence, RI 02906 USA

来源：

CRITICAL CARE | 2010年 / 14卷 / 02期

关键词：

POLYMICROBIAL SEPSIS; INJURY; TRAUMA;

D O I：

10.1186/cc8897

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

During the past decade, there have been an increasing number of studies investigating the precise role of T regulatory cells in human disease. First recognized for their ability to prevent autoimmunity, T regulatory cells control effector CD4(+) and CD8(+) T lymphocytes and innate immune cells by several different suppressive mechanisms, like cell to cell contact, secretion of inhibitory cytokines and cytolysis. This suppressive function of T regulatory cells could contribute in a similar way to the profound immune dysfunction seen in critical illness whether the latter is due to sepsis or severe injury.

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