Current and Future Use of Intravenous Thrombolysis for Acute Ischemic Stroke

被引：16

作者：

Elijovich, Lucas ^{[2
]}

Chong, Ji Y. ^{[1
]}

机构：

[1] Columbia Univ, St Lukes Roosevelt Hosp Ctr, New York, NY 10025 USA

[2] Columbia Univ, St Lukes Roosevelt Hosp Ctr, New York, NY 10019 USA

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2010年 / 12卷 / 05期

关键词：

Acute ischemic stroke; Thrombolysis; Endovascular treatment; tPA; TISSUE-PLASMINOGEN ACTIVATOR; MECHANICAL THROMBECTOMY; RANDOMIZED-TRIAL; PART I; RT-PA; ASSOCIATION; CARE; ALTEPLASE; IMPLEMENTATION; TELEMEDICINE;

D O I：

10.1007/s11883-010-0121-8

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Stroke is a common and disabling condition. Intravenous tissue plasminogen activator (tPA) administered within 3 h of symptom onset is the standard therapy for eligible patients with acute ischemic stroke. Unfortunately, because of the time limitation, very few patients with ischemic stroke actually receive this treatment. In order to increase the number of patients who may benefit from acute treatment, recent research has focused on expanding the time window for thrombolysis and improving its efficacy to ultimately improve patient outcome.

引用

页码：316 / 321

页数：6

共 24 条

[1] Guidelines for the early management of adults with ischemic stroke - A guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the atherosclerotic peripheral vascular disease and quality of care outcomes in research interdisciplinary working groups [J].

Adams, Harold P., Jr. ;

del Zoppo, Gregory ;

Alberts, Mark J. ;

Bhatt, Deepak L. ;

Brass, Lawrence ;

Furlan, Anthony ;

Grubb, Robert L. ;

Higashida, Randall T. ;

Jauch, Edward C. ;

Kidwell, Chelsea ;

Lyden, Patrick D. ;

Morgenstern, Lewis B. ;

Qureshi, Adnan I. ;

Rosenwasser, Robert H. ;

Scott, Phillip A. ;

Wijdicks, Eelco F. M. .

STROKE, 2007, 38 (05) :1655-1711

[2] Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study [J].

Albers, Gregory W. ;

Thijs, Vincent N. ;

Wechsle, Lawrence ;

Kemp, Stephanie ;

Schlaug, Gottfried ;

Skalabrin, Elaine ;

Bammer, Roland ;

Kakuda, Wataru ;

Lansberg, Maarten G. ;

Shuaib, Ashfaq ;

Coplin, William ;

Hamilton, Scott ;

Moseley, Michael ;

Marks, Michael P. .

ANNALS OF NEUROLOGY, 2006, 60 (05) :508-517

[3] Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke [J].

Alexandrov, AV ;

Molina, CA ;

Grotta, JC ;

Garami, Z ;

Ford, SR ;

Alvarez-Sabin, J ;

Montaner, J ;

Saqqur, M ;

Demchuk, AM ;

Moye, LA ;

Hill, MD ;

Wojner, AW ;

Al-Senani, F ;

Burgin, S ;

Calleja, S ;

Campbell, M ;

Chen, CI ;

Chernyshev, O ;

Choi, J ;

El-Mitwalli, A ;

Felberg, R ;

Ford, S ;

Garami, Z ;

Irr, W ;

Grotta, J ;

Hall, C ;

Iguchi, Y ;

Ireland, J ;

Labiche, L ;

Malkoff, M ;

Morgenstern, L ;

Noser, E ;

Okon, N ;

Piriyawat, P ;

Robinson, D ;

Shaltoni, H ;

Shaw, S ;

Uchino, K ;

Yatsu, F ;

Alvarez-Sabín, J ;

Arenillas, JF ;

Huertas, R ;

Molina, C ;

Montaner, J ;

Ribó, M ;

Rubiera, M ;

Santamarina, E ;

Saqqur, M ;

Alchtar, N ;

O'Rourke, F .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (21) :2170-2178

[4] Acute stroke care in the US - Results from 4 pilot prototypes of the Paul Coverdell National Acute Stroke Registry [J].

Arora, S ;

Broderick, JP ;

Frankel, M ;

Heinrich, JP ;

Hickenbottom, S ;

Karp, H ;

LaBresh, KA ;

Malarcher, A ;

Mensah, G ;

Moomaw, CJ ;

Reeves, MJ ;

Schwamm, L ;

Weiss, P .

STROKE, 2005, 36 (06) :1232-1240

[5] Telemedicine for safe and extended use of thrombolysis in stroke -: The Telemedic Pilot Project for Integrative Stroke Care (TEMPiS) in Bavaria [J].

Audebert, HJ ;

Kukla, C ;

von Claranau, SC ;

Kühn, J ;

Vatankhah, B ;

Schenkel, J ;

Ickenstein, GW ;

Haberl, RL ;

Horn, M .

STROKE, 2005, 36 (02) :287-291

[6] The interventional management of stroke (IMS) II study [J].

Broderick, Joseph P. .

STROKE, 2007, 38 (07) :2127-2135

[7] Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial [J].

Davis, Stephen M. ;

Donnan, Geoffrey A. ;

Parsons, Mark W. ;

Levi, Christopher ;

Butcher, Kenneth S. ;

Peeters, Andre ;

Barber, P. Alan ;

Bladin, Christopher ;

De Silva, Deidre A. ;

Byrnes, Graham ;

Chalk, Jonathan B. ;

Fink, John N. ;

Kimber, Thomas E. ;

Schultz, David ;

Hand, Peter J. ;

Frayne, Judith ;

Hankey, Graeme ;

Muir, Keith ;

Gerraty, Richard ;

Tress, Brian M. ;

Desmond, Patricia M. .

LANCET NEUROLOGY, 2008, 7 (04) :299-309

[8] Expansion of the Time Window for Treatment of Acute Ischemic Stroke With Intravenous Tissue Plasminogen Activator A Science Advisory From the American Heart Association/American Stroke Association [J].

del Zoppo, Gregory J. ;

Saver, Jeffrey L. ;

Jauch, Edward C. ;

Adams, Harold P., Jr. .

STROKE, 2009, 40 (08) :2945-2948

[9] Mechanical thrombectomy of intracranial internal carotid occlusion - Pooled results of the MERCI and multi MERCI part I trials [J].

Flint, Alexander C. ;

Duckwiler, Gary R. ;

Budzik, Ronald F. ;

Liebeskind, David S. ;

Smith, Wade S. .

STROKE, 2007, 38 (04) :1274-1280

[10] Intra-arterial prourokinase for acute ischemic stroke - The PROACT II study: A randomized controlled trial [J].

Furlan, A ;

Higashida, R ;

Wechsler, L ;

Gent, M ;

Rowley, H ;

Kase, C ;

Pessin, M ;

Ahuja, A ;

Callahan, F ;

Clark, WM ;

Silver, F ;

Rivera, F .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (21) :2003-2011

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