Unusual Influenza A Viruses in Bats

被引：23

作者：

Mehle, Andrew ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53706 USA

来源：

VIRUSES-BASEL | 2014年 / 6卷 / 09期

关键词：

influenza virus; bats; cross-species transmission; Orthomyxoviridae; host range; SINGLE AMINO-ACID; NATURAL RESERVOIR; VIRAL POLYMERASE; RECEPTOR-BINDING; HIGH VIRULENCE; HOST-RANGE; ADAPTATION; PA; ENDONUCLEASE; TRANSMISSION;

D O I：

10.3390/v6093438

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza A viruses infect a remarkably diverse number of hosts. Two completely new influenza A virus subtypes were recently discovered in bats, dramatically expanding the host range of the virus. These bat viruses are extremely divergent from all other known strains and likely have unique replication cycles. Phylogenetic analysis indicates long-term, isolated evolution in bats. This is supported by a high seroprevalence in sampled bat populations. As bats represent similar to 20% of all classified mammals, these findings suggests the presence of a massive cryptic reservoir of poorly characterized influenza A viruses. Here, we review the exciting progress made on understanding these newly discovered viruses, and discuss their zoonotic potential.

引用

页码：3438 / 3449

页数：12

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