Nature of the T lymphocytes in lymphocyte predominance Hodgkin's disease

被引：3

作者：

Dargent, JL

Schandene, L

Kornreich, A

Lespagnard, L

Cochaux, P

Jagodzinski, R

Capel, P

Velu, T

Neve, P

机构：

[1] Department of Pathology, ULB-Hopital Erasme, Brussels

[2] Department of Immuno-Haematology, ULB-Hopital Erasme, Brussels

[3] Dept. of Med. Genetics/I.R.I.B.H.N, ULB-Hopital Erasme, Brussels

[4] Department of Internal Medicine, ULB-Hopital Erasme, Brussels

[5] Laboratoire de Physiologie Animale, Dept. de Biologie Moléculaire, Université Libre de Bruxelles

[6] Department of Pathology, ULB-Hopital Erasme, B-1070 Brussels, 808, Route de Lennik

来源：

LEUKEMIA & LYMPHOMA | 1997年 / 24卷 / 5-6期

关键词：

lymphocyte predominance Hodgkin's disease; cytokine; T(H)1 phenotype;

D O I：

10.3109/10428199709055592

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Little is known about the function of the T lymphocytes in lymphocyte predominance Hodgkin's disease. We report here the case of a 37-year-old man with a diffuse LPHD, featuring a similar increase in T lymphocytes in both the peripheral blood and the tumor, thus allowing for their characterization by functional assays. These cells were CD4+CD45RO+ and produced high amounts of IL-2 and IFN-gamma, consistent with a T(H)1 type profile. This subset of T helper cells is involved in cellular immunity and could reflect a cytotoxic reaction directed against the neoplastic cells.

引用

页码：545 / 551

页数：7

共 36 条

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