The effects of acid on bone

被引：98

作者：

Bushinsky, DA ^{[1
]}

Frick, KK ^{[1
]}

机构：

[1] Univ Rochester, Sch Med, Dept Med, Nephrol Unit, Rochester, NY 14642 USA

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2000年 / 9卷 / 04期

关键词：

D O I：

10.1097/00041552-200007000-00008

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Metabolic acidosis induces calcium efflux from bone and in the process buffers the additional hydrogen ions. Initially metabolic acidosis stimulates physicochemical mineral dissolution and then cell-mediated bone resorption. Acidosis increases activity of the bone resorbing cells, the osteoclasts, and decreases activity of the bone forming cells, the osteoblasts, Osteoblastic immediate early response genes are inhibited as are genes controlling matrix formation. Curr Opin Nephrol Hypertens 9:369-379. (C) 2000 Lippincott Williams & Wilkins.

引用

页码：369 / 379

页数：11

共 117 条

[1] CALCIURIA OF INCREASED FIXED ACID PRODUCTION IN HUMANS - EVIDENCE AGAINST A ROLE FOR PARATHYROID-HORMONE AND 1,25(OH)2-VITAMIN-D [J].

ADAMS, ND ;

GRAY, RW ;

LEMANN, J .

CALCIFIED TISSUE INTERNATIONAL, 1979, 28 (03) :233-238

[2] INTRACELLULAR ACID-BASE REGULATION .I. RESPONSE OF MUSCLE CELLS TO CHANGES IN CO2 TENSION OR EXTRACELLULAR BICARBONATE CONCENTRATION [J].

ADLER, S ;

ROY, A ;

RELMAN, AS .

JOURNAL OF CLINICAL INVESTIGATION, 1965, 44 (01) :8-&

[3]

[Anonymous], MINER METABOL

[4]

[Anonymous], REGULATION ACID BASE

[5] A COMPARATIVE-STUDY OF DISAGGREGATED CHICK AND RAT OSTEOCLASTS INVITRO - EFFECTS OF CALCITONIN AND PROSTAGLANDINS [J].

ARNETT, TR ;

DEMPSTER, DW .

ENDOCRINOLOGY, 1987, 120 (02) :602-608

[6] EFFECT OF PH ON BONE-RESORPTION BY RAT OSTEOCLASTS INVITRO [J].

ARNETT, TR ;

DEMPSTER, DW .

ENDOCRINOLOGY, 1986, 119 (01) :119-124

[7] Stimulation of osteopontin mRNA expression in HL-60 cells is independent of differentiation [J].

Atkins, KB ;

Simpson, RU ;

Somerman, MJ .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1997, 343 (02) :157-163

[8] THE SKELETON AS AN ION-EXCHANGE SYSTEM - IMPLICATIONS FOR THE ROLE OF ACID-BASE IMBALANCE IN THE GENESIS OF OSTEOPOROSIS [J].

BARZEL, US .

JOURNAL OF BONE AND MINERAL RESEARCH, 1995, 10 (10) :1431-1436

[9]

BARZEL US, 1970, OSTEOPOROSIS

[10]

BARZEL US, 1976, OSTEOPOROSIS, V2

← 1 2 3 4 5 6 7 8 9 10 →